Polyketides

Anticancer Agents from Unique Natural Products Sources

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The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) "Anticancer Agents from Unique Natural Products Sources, CA 67786" was first awarded in September 1995. The goal of the pr...

Goniothalamus Species: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?

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Irrespective of the presence of cytotoxic acetogenins and styryl-lactones in the genus Goniothalamus, only 22 species in the genus Goniothalamus, out of 160 species (13.7%) have so far been inves...

Dietary Administration of Asimina triloba (Paw Paw) Extract Increases Tumor Latency in N-Methyl-N-nitrosourea-Treated Rats

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The paw paw tree, Asimina triloba (L.) Dunal (Annonaceae), contains more than 50 bioactive components, primarily annonaceous acetogenins. Some therapeutic activities have been associated with thi...

Antioxidant Constituents from Xylopia championii

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Xylopia championii Hook. f. & Thoms. (Annonaceae) is endemic to Sri Lanka. The antioxidant and antifungal activities of five alkaloids, oxopurpureine, (+)-laudanidine, (-)-discretine, nordicentri...

Two new cytotoxic acetogenins from Annona squamosa

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Two new annonaceous acetogenins named as squamostanin-A and squamostanin-B were isolated from 95% EtOH extract of the seeds of Annona squamosa. Their structures were determined by spectroscopic m...

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